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Bone morphogenetic protein 2 promotes primordial follicle formation in the ovary

29 Jul 2015

Abstract excerpt

Primordial follicles (PF) are formed when somatic cells differentiate into flattened pregranulosa cells, invaginate into the oocyte nests and encircle individual oocytes. We hypothesize that BMP2 regulates PF formation by promoting the transition of germ cells into oocytes and somatic cells into pregranulosa cells. E15 hamster ovaries were cultured for 8 days corresponding to postnatal day 8 (P8) in vivo, with or...

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PMID: 26219655
DOI: 10.1038/srep12664

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