Article

Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary

2001-06-01

Abstract excerpt

Previous studies have proposed the involvement of caspase-3, a downstream executioner enzyme common to many paradigms of programmed cell death (PCD), in mediating the apoptosis of both germ and somatic cells in the ovary.Herein we used caspase-3 gene knockout mice to directly test for the functional requirement of this protease in oocyte and/or granulosa cell demise.Using both in vivo and in vitro approaches, we d...

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Literature Corpus work: eb544dd1-a52c-597d-a842-25e0a6332a26
DOI: 10.1210/en.142.6.2468

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