Article
Growth inhibition by anchorage-deficiency is associated with increased level but reduced phosphorylation of mutant p53.
Japanese journal of cancer research : Gann - 1 Apr 1992
Takahashi K, Suzuki K, Uehara Y, Ono T
Abstract excerpt
Human breast carcinoma MCF-7 cells seeded on type I collagen-coated dishes were provided with an anchor via the collagen receptor, integrin, and grew as actively as those in plastic tissue culture dishes. In contrast, cells seeded on a layer of soft agar became anchorage-deficient and their growth was significantly inhibited, although the cell viability and the cell cycle distribution were unaffected....
Topics
- Amino Acids
- Antibiotics, Antineoplastic
- Autoradiography
- Benzoquinones
- Breast Neoplasms
- Cell Adhesion
- Cell Division
- Cell Line
- Female
- Genes, p53
- Humans