Article
Dopamine beta-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation.
Human genetics - 1 May 1998
Cubells J F, van Kammen D P, Kelley M E, Anderson G M, O'Connor D T, Price L H, Malison R, Rao P A, Kobayashi K, Nagatsu T, Gelernter J
Abstract excerpt
Levels of the enzyme dopamine beta-hydroxylase (DbetaH) in the plasma and cerebrospinal fluid (CSF) are closely related biochemical phenotypes. Both are under strong genetic control. Linkage and association studies suggest the structural gene encoding DbetaH (locus name, DBH) is a major locus influencing plasma activity of DbetaH. This study examined relationships of DBH genotype determined at two polymorphic...
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