Article
A polymorphism in the dopamine beta-hydroxylase gene is associated with "paranoid ideation" in patients with major depression.
Biological psychiatry - 1 Mar 2002
Wood Jordan G, Joyce Peter R, Miller Allison L, Mulder Roger T, Kennedy Martin A
Abstract excerpt
BACKGROUND: Increased dopaminergic activity may play a primary role in psychotic depression. Dopamine beta-hydroxylase (DbetaH) catalyses the key step in biosynthesis of the neurotransmitter noradrenaline from dopamine, and low DbetaH activity is a possible risk factor for developing psychotic depression. An exon 2 polymorphism (DBH*444 g/a) of the DbetaH gene (DBH) is significantly associated with both serum and...
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