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Article

Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees.

Psychiatric genetics - 1 Mar 2002

Swift-Scanlan T, Lan T-H, Fallin M D, Coughlin J M, Potash J B, DePaulo J R, McInnis M G

Abstract excerpt

A strong genetic association between the NOTCH4 locus on chromosome 6 and schizophrenia was recently reported. Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. In addition, we analyzed a subset of our...

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Source

Identifiers

PMID: 11901359
DOI: 10.1097/00041444-200203000-00006

Genes

NOTCH4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees.PMID 11901359Read ↗

Neither single-marker nor haplotype analyses support an association between genetic variation near NOTCH4 and bipolar disorder.Semantic proximity Read ↗

Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses.Semantic proximity Read ↗

No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis.Semantic proximity Read ↗

The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals.Semantic proximity Read ↗

The NOTCH4 locus is associated with susceptibility to schizophrenia.Semantic proximity Read ↗

Is NOTCH4 associated with schizophrenia?Semantic proximity Read ↗

Family-based association study of Neuregulin 1 with psychotic bipolar disorder.Semantic proximity Read ↗

Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland.Semantic proximity Read ↗

NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder.Semantic proximity Read ↗

A family-based and case-control association study of the NOTCH4 gene and schizophrenia.Semantic proximity Read ↗

Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects.Semantic proximity Read ↗

Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples.Semantic proximity Read ↗

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