Article
Family-based association study of Neuregulin 1 with psychotic bipolar disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2009
Goes Fernando S, Willour Virginia L, Zandi Peter P, Belmonte Pamela L, MacKinnon Dean F, Mondimore Francis M, Schweizer Barbara, Gershon Elliot S, McMahon Francis J, Potash James B
Abstract excerpt
The Neuregulin 1 gene (NRG1) has been associated with schizophrenia, and, to a lesser extent, with bipolar disorder (BP). We investigated the association of NRG1 with BP in a large family sample, and then performed analyses according to the presence of psychotic features or mood-incongruent psychotic features. We genotyped 116 tagSNPs and four Icelandic "core" SNPs in 1,199 subjects from 314 nuclear families. Of...
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