Article
Acceleration of chromosomal instability of BRCA1-associated hereditary breast cancers by p53 abnormality.
The breast journal - 1 Jan 2000
Miyoshi Yasuo, Iwao Kyoko, Ikeda Noriko, Egawa Chiyomi, Noguchi Shinzaburo
Abstract excerpt
Chromosomal instability (CIN) of BRCA1-associated hereditary breast cancers was studied by fluorescence in situ hybridization of chromosomes 1, 11, and 17. CIN values (the percentage of cells with a nonmodal chromosome) were obtained for each of three chromosomes, and their average was finally used as the CIN value of the sample. BRCA1-associated tumors showed a significantly (p = 0.0089) higher CIN value than...
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