Article
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 1995
Qu A, Leahy D J
Abstract excerpt
We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion molecules 1 and 3 and can exist in both low- and high-affinity states. The metal-bound form reported here is likely to represent a high-affini...
Topics
- Amino Acid Sequence
- Binding Sites
- Cell Line
- Cloning, Molecular
- Crystallization
- Crystallography, X-Ray
- Escherichia coli
- Humans
- Lymphocyte Function-Associated Antigen-1
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Structure, Secondary
- Recombinant Proteins
- Sequence Homology, Amino Acid
- von Willebrand Diseases
- von Willebrand Factor