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Article

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 1995

Qu A, Leahy D J

Abstract excerpt

We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion molecules 1 and 3 and can exist in both low- and high-affinity states. The metal-bound form reported here is likely to represent a high-affinity state. The CD11a I-domain structure reveals a strained hydrophobic ridge adjacent to the bound metal ion that may...

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Identifiers

PMID: 7479767
DOI: 10.1073/pnas.92.22.10277
PMCID: PMC40779

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