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Targeting mutant p53 for cancer therapy

26 Jun 2016

Abstract excerpt

The p53 tumor suppressor protein serves as a major barrier against cancer; consequently, mutations in the TP53 gene, encoding p53, are the most frequent single genetic alteration in human cancer, occurring in about half of all individual cancer cases [1]. Besides abrogating the tumor suppressive effects of the wild type (WT) p53 protein, many of the TP53 mutations endow the mutant p53 protein with new oncogenic...

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PMID: 27347904
DOI: 10.18632/aging.100992

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