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Article

Association of a null mutation in the CNTF gene with early onset of multiple sclerosis.

Archives of neurology - 1 Mar 2002

Giess Ralf, Mäurer Mathias, Linker Ralf, Gold Ralf, Warmuth-Metz Monika, Toyka Klaus V, Sendtner Michael, Rieckmann Peter

Abstract excerpt

BACKGROUND: Immune-mediated demyelination and axonal damage lead to early functional impairment in multiple sclerosis (MS). Ciliary neurotrophic factor (CNTF) is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attack...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11890844
DOI: 10.1001/archneur.59.3.407

Genes

CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11890844-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Association of a null mutation in the CNTF gene with early onset of multiple sclerosis.PMID 11890844Read ↗

A null mutation within the ciliary neurotrophic factor (CNTF)-gene: implications for susceptibility and disease severity in patients with multiple sclerosis.Semantic proximity Read ↗

A null mutation in the human CNTF gene is not causally related to neurological diseases.Semantic proximity Read ↗

[Deficiency of human ciliary neurotropic factor (CNTF) is not causally related to amyotrophic lateral sclerosis (ALS)].Semantic proximity Read ↗

Association between a null mutation in the human ciliary neurotrophic factor (CNTF) gene and increased incidence of psychiatric diseases?Semantic proximity Read ↗

Ciliary neurotrophic factor null alleles are not a risk factor for Charcot-Marie-Tooth disease, hereditary neuropathy with pressure palsies and amyotrophic lateral sclerosis.Semantic proximity Read ↗

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease.Semantic proximity Read ↗

Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor.Semantic proximity Read ↗

A null mutation allele in the CNTF gene and schizophrenic psychoses.Semantic proximity Read ↗

Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males.Semantic proximity Read ↗

Schizophrenia and the ciliary neurotrophic factor (CNTF) gene: no evidence for association.Semantic proximity Read ↗

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