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Article

[Deficiency of human ciliary neurotropic factor (CNTF) is not causally related to amyotrophic lateral sclerosis (ALS)].

Rinsho shinkeigaku = Clinical neurology - 1 Dec 1995

Takahashi R

Abstract excerpt

Ciliary neurotrophic factor (CNTF) promotes the survival of motor neurons in vitro and in vivo. A recent report showed that disruption of the CNTF gene in mice caused motor neuron degeneration. We have found a null mutation in the human CNTF gene. The mutated allele shows a G to A transition prod...

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Identifiers

PMID: 8752458

Genes

CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8752458-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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[Deficiency of human ciliary neurotropic factor (CNTF) is not causally related to amyotrophic lateral sclerosis (ALS)].PMID 8752458Read ↗

A null mutation in the human CNTF gene is not causally related to neurological diseases.Semantic proximity Read ↗

Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Ciliary neurotrophic factor null alleles are not a risk factor for Charcot-Marie-Tooth disease, hereditary neuropathy with pressure palsies and amyotrophic lateral sclerosis.Semantic proximity Read ↗

Decrease in the ciliary neurotrophic factor of the spinal cord in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Association between a null mutation in the human ciliary neurotrophic factor (CNTF) gene and increased incidence of psychiatric diseases?Semantic proximity Read ↗

Association of a null mutation in the CNTF gene with early onset of multiple sclerosis.Semantic proximity Read ↗

A null mutation within the ciliary neurotrophic factor (CNTF)-gene: implications for susceptibility and disease severity in patients with multiple sclerosis.Semantic proximity Read ↗

Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease.Semantic proximity Read ↗

Schizophrenia and the ciliary neurotrophic factor (CNTF) gene: no evidence for association.Semantic proximity Read ↗

Ciliary neurotrophic factor (CNTF) genotype and body composition.Semantic proximity Read ↗

Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women.Semantic proximity Read ↗

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