Article
A null mutation allele in the CNTF gene and schizophrenic psychoses.
Neuroreport - 31 May 1996
Thome J, Durany N, Harsányi A, Foley P, Palomo A, Kornhuber J, Weijers H G, Baumer A, Rösler M, Cruz-Sánchez F F, Beckmann H, Riederer P
Abstract excerpt
The maldevelopmental theory postulates disturbances in neural development as crucial factors in the aetiopathogenesis of schizophrenia. Neurotrophic factors, including ciliary neurotrophic factor (CNTF), play a central role in the regulation of such development. A mutation has been described for the CNTF gene, whereby subjects homozygous for the mutation lack CNTF. The polymerase chain reaction was used to...
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