Article
Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies.
Clinical immunology (Orlando, Fla.) - 1 Mar 2002
Robles David T, Eisenbarth George S, Wang Tianbao, Erlich Henry A, Bugawan Teodorica L, Babu Sunanda R, Barriga Kathy, Norris Jill M, Hoffman Michelle, Klingensmith Georgeanna, Yu Liping, Rewers Marian
Abstract excerpt
A total of 21,000 general population newborns (NECs) and 693 young siblings-offspring of patients with type 1A diabetes (SOCs) were class II genotyped and 293 NECs and 72 SOCs with the high-risk genotype, DR3/4, DQB1*0302 have been prospectively evaluated. Seventeen individuals who converted to persistent autoantibody positivity and two autoantibody-negative control groups (35 SOCs and 24 NECs) were typed for...
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