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Article

Paraoxonase-1 L55M polymorphism is associated with an abnormal oral glucose tolerance test and differentiates high risk coronary disease families.

The Journal of clinical endocrinology and metabolism - 1 Mar 2002

Deakin Sara, Leviev Ilia, Nicaud Viviane, Brulhart Meynet Marie-Claude, Tiret Laurence, James Richard W

Abstract excerpt

Polymorphisms of the gene for the antioxidant enzyme, paraoxonase-1 (PON1), have been identified as risk factors for coronary disease (CHD), notably in diabetic patients. The polymorphisms have also been linked with other diabetic complications. The present study analyzed glucose metabolism as a function of PON1 polymorphisms in young healthy nondiabetic men from families with premature CHD and matched controls....

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Source

Identifiers

PMID: 11889198
DOI: 10.1210/jcem.87.3.8335

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Paraoxonase-1 L55M polymorphism is associated with an abnormal oral glucose tolerance test and differentiates high risk coronary disease families.PMID 11889198Read ↗

PON1 M/L55 mutation protects high-risk patients against coronary artery disease.Semantic proximity Read ↗

Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes.Semantic proximity Read ↗

The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender.Semantic proximity Read ↗

Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus.Semantic proximity Read ↗

Association between p.Leu54Met polymorphism at the paraoxonase-1 gene and plantar fascia thickness in young subjects with type 1 diabetes.Semantic proximity Read ↗

Paraoxonase activity and coronary heart disease risk in healthy middle-aged males: the PRIME study.Semantic proximity Read ↗

The effect of paraoxonase 1 (PON1) gene polymorphisms T(-107)C and L55M and diet composition on serum PON1 activity in women.Semantic proximity Read ↗

Factors associated with paraoxonase genotypes and activity in a diverse, young, healthy population: the Coronary Artery Risk Development in Young Adults (CARDIA) study.Semantic proximity Read ↗

Can paraoxonase 1 polymorphisms (L55 M and Q192 R) protect children with type 1 diabetes against lipid abnormalities?Semantic proximity Read ↗

Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification.Semantic proximity Read ↗

Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus.Semantic proximity Read ↗

Human paraoxonase 1 gene polymorphisms and the risk of coronary heart disease: a community-based study.Semantic proximity Read ↗

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