Article
Increased expression of the multidrug efflux genes<i>acrAB</i>occurs during slow growth of<i>Escherichia coli</i>
1 Jan 2002
Abstract excerpt
Intrinsic antimicrobial resistance of Escherichia coli is elicited by the gene products of the multidrug efflux acrAB-tolC operon. In this paper, we have shown that acrAB is regulated as a function of the growth rate of E. coli during growth in batch and chemostat culture. In chemostat culture, expression of acrAB is inversely related to growth rate irrespective of the limiting nutrient. The level of expression...
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