Expression of Multidrug Efflux Pump Genes <i>acrAB-tolC</i> , <i>mdfA</i> , and <i>norE</i> in <i>Escherichia coli</i> Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance

Abstract excerpt

In a single quantitative study, we measured acrA, acrB, tolC, mdfA, and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC, mdfA, and norE expression did not. The order of abundance of efflux pump transcripts in all fluoroquinolone-susceptible isolates was tolC (highest), then acrA and...

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