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Article

High-Level Fluoroquinolone-Resistant Clinical Isolates of <i>Escherichia coli</i> Overproduce Multidrug Efflux Protein AcrA

1 Dec 2000

Abstract excerpt

Immunoblotting with antibody against AcrA, an obligatory component of the AcrAB multidrug efflux system, showed that this protein was overexpressed by >/=170% in 9 of 10 clinical isolates of Esherichia coli with high-level ciprofloxacin resistance (MICs, >/=32 microg/ml) but not in any of the 15 isolates for which the MIC was </=1 microg/ml.

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PMID: 11083655
DOI: 10.1128/aac.44.12.3441-3443.2000

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