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Article

Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and expression of proton gradient-dependent multidrug efflux pump genes.

Antimicrobial agents and chemotherapy - 1 Aug 2005

Viveiros Miguel, Jesus Ana, Brito Mafalda, Leandro Clara, Martins Marta, Ordway Diane, Molnar Ana Maria, Molnar Joseph, Amaral Leonard

Abstract excerpt

Expression of eight transporter genes of Escherichia coli K-12 and its DeltaacrAB mutant prior to and after induction of both strains to tetracycline resistance and after reversal of induced resistance were analyzed by quantitative reverse transcriptase PCR. All transporter genes were overexpressed after induced resistance with acrF being 80-fold more expressed in the DeltaacrAB tetracycline-induced strain.

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Share to Drug Resistance, Multiple, Bacterial
Share to Escherichia coli K12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16048990
DOI: 10.1128/AAC.49.8.3578-3582.2005
PMCID: PMC1196278

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