Apical budding of a recombinant influenza A virus expressing a hemagglutinin protein with a basolateral localization signal.

doi:10.1128/jvi.76.7.3544-3553.2002

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Article

Apical budding of a recombinant influenza A virus expressing a hemagglutinin protein with a basolateral localization signal.

Journal of virology - 1 Apr 2002

Mora Rosalia, Rodriguez-Boulan Enrique, Palese Peter, García-Sastre Adolfo

Abstract excerpt

Influenza virions bud preferentially from the apical plasma membrane of infected epithelial cells, by enveloping viral nucleocapsids located in the cytosol with its viral integral membrane proteins, i.e., hemagglutinin (HA), neuraminidase (NA), and M2 proteins, located at the plasma membrane. Because individually expressed HA, NA, and M2 proteins are targeted to the apical surface of the cell, guided by apical...

Topics

Animals
Cell Line
Cell Membrane
Cell Polarity
Hemagglutinin Glycoproteins, Influenza Virus
Influenza A virus
Mutation
Protein Transport
Recombination, Genetic
Transformation, Genetic
Virus Assembly

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Identifiers

PMID: 11884578
DOI: 10.1128/jvi.76.7.3544-3553.2002
PMCID: PMC136015

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