Article
Apical budding of a recombinant influenza A virus expressing a hemagglutinin protein with a basolateral localization signal.
Journal of virology - 1 Apr 2002
Mora Rosalia, Rodriguez-Boulan Enrique, Palese Peter, García-Sastre Adolfo
Abstract excerpt
Influenza virions bud preferentially from the apical plasma membrane of infected epithelial cells, by enveloping viral nucleocapsids located in the cytosol with its viral integral membrane proteins, i.e., hemagglutinin (HA), neuraminidase (NA), and M2 proteins, located at the plasma membrane. Because individually expressed HA, NA, and M2 proteins are targeted to the apical surface of the cell, guided by apical...
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