Article
Genetic contribution of the interleukin-10 promoter polymorphism in endometriosis susceptibility.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Jan 2002
Kitawaki Jo, Obayashi Hiroshi, Ohta Mitsuhiro, Kado Noriko, Ishihara Hiroaki, Koshiba Hisato, Kusuki Izumi, Tsukamoto Katsumi, Hasegawa Goji, Nakamura Naoto, Yoshikawa Toshikazu, Honjo Hideo
Abstract excerpt
PROBLEM: Interleukin-10 (IL-10) is an important immunomodulatory cytokine. The aim of this study was to investigate whether polymorphisms of the IL-10 gene promoter polymorphisms may be responsible in part for genetic susceptibility to endometriosis. METHODS OF STUDY: Polymorphisms at position -1082 and -592 in the IL-10 promoter region were determined in 196 patients with endometriosis and 160 fertile healthy...
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