Article
Association of interleukin--10 promoter polymorphism and endometriosis.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Jan 2011
Riiskjaer Mads, Nielsen Kaspar, Steffensen Rudi, Erikstrup Christian, Forman Axel, Kruse Christina
Abstract excerpt
PROBLEM: inflammatory processes are believed to play an important role in the pathogenesis of endometriosis. Interleukin-10 (IL-10) is an important immunoregulatory cytokine. The biological actions are mainly inhibitory including inactivation of macrophages and inhibition of pro-inflammatory cytokines. Twin and family studies have shown that between 50 and 75% of the observed variability of IL-10 secretion was...
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