Article
Knockout mouse model for Fxr2: a model for mental retardation.
Human molecular genetics - 1 Mar 2002
Bontekoe Carola J M, McIlwain Kellie L, Nieuwenhuizen Ingeborg M, Yuva-Paylor Lisa A, Nellis Anna, Willemsen Rob, Fang Zhe, Kirkpatrick Laura, Bakker Cathy E, McAninch Robin, Cheng Ngan Ching, Merriweather Michelle, Hoogeveen Andre T, Nelson David, Paylor Richard, Oostra Ben A
Abstract excerpt
Fragile X syndrome is a common form of mental retardation caused by the absence of the FMR1 protein, FMRP. Fmr1 knockout mice exhibit a phenotype with some similarities to humans, such as macro-orchidism and behavioral abnormalities. Two homologs of FMRP have been identified, FXR1P and FXR2P. These proteins show high sequence similarity, including all functional domains identified in FMRP, such as RNA binding...
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