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Article

(Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features.

Human molecular genetics - 1 May 2000

Peier A M, McIlwain K L, Kenneson A, Warren S T, Paylor R, Nelson D L

Abstract excerpt

Fragile X syndrome is a common cause of mental retardation involving loss of expression of the FMR1 gene. The role of FMR1 remains undetermined but the protein appears to be involved in RNA metabolism. Fmr1 knockout mice exhibit a phenotype with some similarities to humans, such as macroorchidism and behavioral abnormalities. As a step toward understanding the function of FMR1 and the determination of the...

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Source

Identifiers

PMID: 10767339
DOI: 10.1093/hmg/9.8.1145

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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