Article
Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset.
Journal of autoimmunity - 1 Feb 2002
Hampe Christiane S, Hammerle Lisa P, Bekris Lynn, Ortqvist Eva, Persson Bengt, Lernmark Ake
Abstract excerpt
Autoantibodies to GAD65 (GAD65Ab) are prominent in type 1 diabetes. These autoantibodies may be present both years before and after the clinical diagnosis of type 1 diabetes and are widely used as a marker for the disease. Recently it has been demonstrated that progression to type 1 diabetes is accompanied by GAD65Ab epitope maturation. Here we examine whether autoantibody maturation processes also progress after...
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