Article
Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes.
Diabetologia - 1 May 2005
Schlosser M, Banga J P, Madec A M, Binder K A, Strebelow M, Rjasanowski I, Wassmuth R, Gilliam L K, Luo D, Hampe C S
Abstract excerpt
AIMS/HYPOTHESIS: Progression to type 1 diabetes is associated with intramolecular epitope spreading to disease-specific antibody epitopes located in the middle region of glutamic acid decarboxylase 65 (GAD65). METHODS: The relationship between intramolecular epitope spreading of autoantibodies sp...
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