Article
A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape.
Genetics - 1 Dec 2002
Suzuki Yo, Morris Gail A, Han Min, Wood William B
Abstract excerpt
The signaling pathway initiated by the TGF-beta family member DBL-1 in Caenorhabditis elegans controls body shape in a dose-dependent manner. Loss-of-function (lf) mutations in the dbl-1 gene cause a short, small body (Sma phenotype), whereas overexpression of dbl-1 causes a long body (Lon phenotype). To understand the cellular mechanisms underlying these phenotypes, we have isolated suppressors of the Sma...
Topics
- Animals
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Collagen
- DNA, Helminth
- Genes, Helminth
- Genes, Reporter
- Green Fluorescent Proteins
- Luminescent Proteins
- Models, Biological
- Molecular Sequence Data
- Mutation