Article
A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans.
Development (Cambridge, England) - 1 Jan 1999
Suzuki Y, Yandell M D, Roy P J, Krishna S, Savage-Dunn C, Ross R M, Padgett R W, Wood W B
Abstract excerpt
We cloned the dbl-1 gene, a C. elegans homolog of Drosophila decapentaplegic and vertebrate BMP genes. Loss-of-function mutations in dbl-1 cause markedly reduced body size and defective male copulatory structures. Conversely, dbl-1 overexpression causes markedly increased body size and partly com...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Body Constitution
- Body Patterning
- Bone Morphogenetic Proteins
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cloning, Molecular
- Disorders of Sex Development
- Epistasis, Genetic
- Gene Expression Regulation, Developmental
- Genes, Reporter
- Genitalia
- Male
- Molecular Sequence Data
- Mutation
- Neurons