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Article

Functional analysis of the promoter of human sterol 27-hydroxylase gene in HepG2 cells.

Gene - 23 Jan 2002

Garuti Rita, Croce Maria Antonietta, Piccinini Luana, Tiozzo Roberta, Bertolini Stefano, Calandra Sebastiano

Abstract excerpt

Human sterol 27-hydroxylase catalyses the first step in the alternative pathway of bile acids biosynthesis in hepatocytes. However the gene encoding this enzyme (CYP27 gene) is expressed in every tissue and some evidence suggests that this enzyme plays a role in cholesterol homeostasis. Although modulation of CYP27 expression has been reported, the mechanisms underlying the regulation of this gene in human...

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PMID: 11867220
DOI: 10.1016/s0378-1119(01)00874-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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