Article
Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study.
Diabetes - 1 Apr 2007
Hanson Robert L, Craig David W, Millis Meredith P, Yeatts Kimberly A, Kobes Sayuko, Pearson John V, Lee Anne M, Knowler William C, Nelson Robert G, Wolford Johanna K
Abstract excerpt
To identify genetic variants contributing to end-stage renal disease (ESRD) in type 2 diabetes, we performed a genome-wide analysis of 115,352 single nucleotide polymorphisms (SNPs) in pools of 105 unrelated case subjects with ESRD and 102 unrelated control subjects who have had type 2 diabetes for > or =10 years without macroalbuminuria. Using a sliding window statistic of ranked SNPs, we identified a 200-kb...
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