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Article

Proliferation-dependent induction of apoptosis by the retinoid CD437 in p53-mutated keratinocytes.

Journal of molecular medicine (Berlin, Germany) - 1 Jan 2002

Wanner R, Henseleit-Walter U, Wittig B, Kolde G

Abstract excerpt

6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-Naphthalene carboxylic acid (CD437) is a synthetic retinoid with strong apoptogenic properties in various neoplastic cell lines. CD437 was shown to induce apoptosis in malignant human keratinocytes but not in normal keratinocytes. We demonstrate that CD437 is also capable of inducing apoptosis in the non-tumorigenic keratinocyte cell line HaCaT that carries UV-type mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11862326
DOI: 10.1007/s00109-001-0288-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Proliferation-dependent induction of apoptosis by the retinoid CD437 in p53-mutated keratinocytes.PMID 11862326Read ↗

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