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Article

The structure of monoamine oxidase from Aspergillus niger provides a molecular context for improvements in activity obtained by directed evolution.

Journal of molecular biology - 31 Dec 2008

Atkin Kate E, Reiss Renate, Koehler Valentin, Bailey Kevin R, Hart Sam, Turkenburg Johan P, Turner Nicholas J, Brzozowski A Marek, Grogan Gideon

Abstract excerpt

Monoamine oxidase from Aspergillus niger (MAO-N) is a flavoenzyme that catalyses the oxidative deamination of primary amines. MAO-N has been used as the starting model for a series of directed evolution experiments, resulting in mutants of improved activity and broader substrate specificity, suitable for application in the preparative deracemisation of primary, secondary and tertiary amines when used as part of a...

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Identifiers

PMID: 18951902
DOI: 10.1016/j.jmb.2008.09.090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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