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Article

The structure of monoamine oxidase from Aspergillus niger provides a molecular context for improvements in activity obtained by directed evolution.

Journal of molecular biology - 31 Dec 2008

Atkin Kate E, Reiss Renate, Koehler Valentin, Bailey Kevin R, Hart Sam, Turkenburg Johan P, Turner Nicholas J, Brzozowski A Marek, Grogan Gideon

Abstract excerpt

Monoamine oxidase from Aspergillus niger (MAO-N) is a flavoenzyme that catalyses the oxidative deamination of primary amines. MAO-N has been used as the starting model for a series of directed evolution experiments, resulting in mutants of improved activity and broader substrate specificity, suit...

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Identifiers

PMID: 18951902
DOI: 10.1016/j.jmb.2008.09.090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18951902-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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