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Article

Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid.

The Journal of biological chemistry - 30 Mar 2001

Geha R M, Rebrin I, Chen K, Shih J C

Abstract excerpt

Monoamine oxidase (MAO) is responsible for the oxidation of biogenic and dietary amines. It exists as two isoforms, A and B, which have a 70% amino acid identity and different substrate and inhibitor specificities. This study reports the identification of residues responsible for conferring this specificity in human MAO A and B. Using site-directed mutagenesis we reciprocally interchanged three pairs of...

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PMID: 11134050
DOI: 10.1074/jbc.M006972200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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