Article
Organochlorines, p53 mutations in relation to breast cancer risk and survival. A Danish cohort-nested case-controls study.
Breast cancer research and treatment - 1 Jan 2002
Høyer Annette Pernille, Gerdes Anne-Marie, Jørgensen Torben, Rank Fritz, Hartvig Helle Bøggild
Abstract excerpt
Epidemiological studies integrating genetic susceptibility with biological measurements of organochlorine exposure may provide new clues regarding these substances influence on breast cancer etiology. Initial attempts pursuing this avenue has dealt with polymorphisms in the carcinoge metabolizing enzymes cytochrome P450 (CYP1A1). This study examined if mutations in the tumor suppressor gene p53 affected...
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