Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis.

PloS one - 1 Jan 2015

Gimenez Fernanda, Mulik Sachin, Veiga-Parga Tamara, Bhela Siddheshvar, Rouse Barry T

Abstract excerpt

The cornea is a complex tissue that must preserve its transparency to maintain optimal vision. However, in some circumstances, damage to the eye can result in neovascularization that impairs vision. This outcome can occur when herpes simplex virus type 1 (HSV-1) causes the immunoinflammatory lesion stromal keratitis (SK). Potentially useful measures to control the severity of SK are to target angiogenesis which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Herpesvirus 1, Human
Share to Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Pathologic

Share to Nerve Tissue Proteins

Share to Receptors, Cell Surface

Share to Receptors, Immunologic

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 26720197
DOI: 10.1371/journal.pone.0141925
PMCID: PMC4697792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis.PMID 26720197Read ↗

ADAM9 Is Involved in Pathological Retinal NeovascularizationSemantic proximity Read ↗

Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVsSemantic proximity Read ↗

Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularizationSemantic proximity Read ↗

Mechanism for IL-1β-mediated neovascularization unmasked by IL-1β knock-out miceSemantic proximity Read ↗

CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization.Semantic proximity Read ↗

FGF2-induced STAT3 activation regulates pathologic neovascularizationSemantic proximity Read ↗

Healing of Primary and Recurrent Mouse Ocular Herpetic Disease Following Topical Ocular Treatment with an Engineered Fibroblast Growth Factor-1 (FGF-1) is Associated with Increased Frequency and Function of Corneal Anti-Inflammatory M2 MacrophagesSemantic proximity Read ↗

Transgenic mouse models of corneal neovascularization: new perspectives for angiogenesis research.Semantic proximity Read ↗

Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and visionSemantic proximity Read ↗

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1Semantic proximity Read ↗

Blockade of VEGFR1 and 2 Suppresses Pathological Angiogenesis and Vascular Leakage in the EyeSemantic proximity Read ↗

An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.