Article
A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 1995
Lemaitre B, Kromer-Metzger E, Michaut L, Nicolas E, Meister M, Georgel P, Reichhart J M, Hoffmann J A
Abstract excerpt
In this paper we report a recessive mutation, immune deficiency (imd), that impairs the inducibility of all genes encoding antibacterial peptides during the immune response of Drosophila. When challenged with bacteria, flies carrying this mutation show a lower survival rate than wild-type flies. We also report that, in contrast to the antibacterial peptides, the antifungal peptide drosomycin remains inducible in...
Topics
- Animals
- Anti-Bacterial Agents
- Antimicrobial Cationic Peptides
- Bacterial Infections
- Base Sequence
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Genes, Insect
- Genes, Recessive