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Article

Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress.

Infection and immunity - 1 Mar 2002

Tseng Hsing-Ju, McEwan Alastair G, Paton James C, Jennings Michael P

Abstract excerpt

psaA encodes a 37-kDa pneumococcal lipoprotein which is part of an ABC Mn(II) transport complex. Streptococcus pneumoniae D39 psaA mutants have previously been shown to be significantly less virulent than wild-type D39, but the mechanism underlying the attenuation has not been resolved. In this study, we have shown that psaA and psaD mutants are highly sensitive to oxidative stress, i.e., to superoxide and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11854257
DOI: 10.1128/IAI.70.3.1635-1639.2002
PMCID: PMC127802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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