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Article

Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice.

Oncogene - 7 Feb 2002

Chen Qin, Ash John D, Branton Phil, Fromm Larry, Overbeek Paul A

Abstract excerpt

Previous studies have shown that the adenovirus E1A oncoprotein can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the transcriptional coactivators CBP/p300. In this study, wild-type E1A12S or two deletion mutants (delN, which binds pRb but not CBP/p300; delCR2, which binds to CBP/p300 but not pRb) were linked to the lens-specific alphaA-crystallin promoter, and used to generate...

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Source

Identifiers

PMID: 11850820
DOI: 10.1038/sj.onc.1205050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice.PMID 11850820Read ↗

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