Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence.

PLoS genetics - 1 Feb 2008

Kleinjan Dirk A, Bancewicz Ruth M, Gautier Philippe, Dahm Ralf, Schonthaler Helia B, Damante Giuseppe, Seawright Anne, Hever Ann M, Yeyati Patricia L, van Heyningen Veronica, Coutinho Pedro

Abstract excerpt

Gene duplication is a major driver of evolutionary divergence. In most vertebrates a single PAX6 gene encodes a transcription factor required for eye, brain, olfactory system, and pancreas development. In zebrafish, following a postulated whole-genome duplication event in an ancestral teleost, duplicates pax6a and pax6b jointly fulfill these roles. Mapping of the homozygously viable eye mutant sunrise identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Bacterial
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Abnormalities

Share to Gene Duplication

Share to Genes, Homeobox

Share to Paired Box Transcription Factors

Share to PAX6 Transcription Factor

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18282108
DOI: 10.1371/journal.pgen.0040029
PMCID: PMC2242813

Genes

ELP4
PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence.PMID 18282108Read ↗

Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences.Semantic proximity Read ↗

New 3' elements control Pax6 expression in the developing pretectum, neural retina and olfactory region.Semantic proximity Read ↗

New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone.Semantic proximity Read ↗

Evolution of developmental roles of Pax2/5/8 paralogs after independent duplication in urochordate and vertebrate lineages.Semantic proximity Read ↗

A human homologue of the Drosophila eyes absent gene underlies Branchio-Oto-Renal (BOR) syndrome and identifies a novel gene familySemantic proximity Read ↗

Mammalian Pax genes.Semantic proximity Read ↗

Functional conservation of the Drosophila gooseberry gene and its evolutionary alleles.Semantic proximity Read ↗

Identification and Expression of Conserved and Novel RNA Variants of Medaka pax6b Gene.Semantic proximity Read ↗

Six family genes--structure and function as transcription factors and their roles in development.Semantic proximity Read ↗

Genetic and biochemical diversity in the Pax gene family.Semantic proximity Read ↗

Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.Semantic proximity Read ↗

PAX6 and congenital eye malformations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.