Article
Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences.
PLoS genetics - 1 Jan 2013
Ravi Vydianathan, Bhatia Shipra, Gautier Philippe, Loosli Felix, Tay Boon-Hui, Tay Alice, Murdoch Emma, Coutinho Pedro, van Heyningen Veronica, Brenner Sydney, Venkatesh Byrappa, Kleinjan Dirk A
Abstract excerpt
Pax6 is a developmental control gene essential for eye development throughout the animal kingdom. In addition, Pax6 plays key roles in other parts of the CNS, olfactory system, and pancreas. In mammals a single Pax6 gene encoding multiple isoforms delivers these pleiotropic functions. Here we provide evidence that the genomes of many other vertebrate species contain multiple Pax6 loci. We sequenced...
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