Article
Increased incidence of mitochondrial cytochrome c-oxidase gene mutations in patients with myelodysplastic syndromes.
British journal of haematology - 1 Mar 2002
Reddy Poluru L, Shetty Vilasini T, Dutt Diya, York Aaron, Dar Saleem, Mundle Suneel D, Allampallam Krishnan, Alvi Sairah, Galili Naomi, Saberwal Gurveen Sethi, Anthwal Shalini, Shaikh Malihi, Suleman Samia, Kamal Shaista Y, Raza Azra
Abstract excerpt
Mitochondria (mt) play an important role in both apoptosis and haem synthesis. The present study was conducted to determine DNA mutations in mitochondrial encoded cytochrome c-oxidase I and II genes. Bone marrow (BM) biopsy and aspirate, peripheral blood (PB) and buccal smear samples were collected from 20 myelodysplastic syndrome (MDS) patients and 10 age-matched controls. Cytochrome c-oxidase I (CO I) and II...
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