Article
Mitochondria in hematopoiesis and hematological diseases.
Oncogene - 7 Aug 2006
Fontenay M, Cathelin S, Amiot M, Gyan E, Solary E
Abstract excerpt
Mitochondria are involved in hematopoietic cell homeostasis through multiple ways such as oxidative phosphorylation, various metabolic processes and the release of cytochrome c in the cytosol to trigger caspase activation and cell death. In erythroid cells, the mitochondrial steps in heme synthesis, iron (Fe) metabolism and Fe-sulfur (Fe-S) cluster biogenesis are of particular importance. Mutations in the...
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