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Article

Single amino acid substitutions in conserved extracellular domains of E-cadherin differ in their functional consequences.

Journal of molecular biology - 30 Nov 2001

Handschuh G, Luber B, Hutzler P, Höfler H, Becker K F

Abstract excerpt

The calcium-dependent homophilic cell adhesion molecule E-cadherin typically connects epithelial cells. The extracellular portion of the mature transmembrane protein consists of five homologous domains. The four sequences linking these domains contain the structural amino acid motif DXXD that is thought to be involved in direct calcium binding. In gastric cancer patients mutations affecting this motif between the...

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Identifiers

PMID: 11846558
DOI: 10.1006/jmbi.2001.5143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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