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Article

DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo.

Human molecular genetics - 15 Apr 2014

Simões-Correia Joana, Silva Diana I, Melo Soraia, Figueiredo Joana, Caldeira Joana, Pinto Marta T, Girão Henrique, Pereira Paulo, Seruca Raquel

Abstract excerpt

E-cadherin (Ecad) is a well-known invasion suppressor and its loss of expression is common in invasive carcinomas. Germline Ecad mutations are the only known genetic cause of hereditary diffuse gastric cancer (HDGC), demonstrating the causative role of Ecad impairment in gastric cancer. HDGC-asso...

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Identifiers

PMID: 24293545
DOI: 10.1093/hmg/ddt602

Genes

DNAJB4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24293545-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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