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Article

Caspase-mediated Parkin Cleavage in Apoptotic Cell Death

1 May 2002

Abstract excerpt

The parkin protein is important for the survival of the neurons that degenerate in Parkinson's disease as demonstrated by disease-causing lesions in the parkin gene. The Chinese hamster ovary and the SH-SY5Y cell line stably expressing recombinant human parkin combined with epitope-specific parkin antibodies were used to investigate the proteolytic processing of human parkin during apoptosis by immunoblotting....

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Identifiers

PMID: 11839750
DOI: 10.1074/jbc.m111534200

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Caspase-mediated Parkin Cleavage in Apoptotic Cell DeathPMID 11839750Read ↗

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Mutations in the Parkinson’s Disease-Associated PARK2 Gene Are Accompanied by Imbalance in Programmed Cell Death SystemsSemantic proximity Read ↗

Parkin induces apoptotic cell death in TNF-α-treated cervical cancer cellsSemantic proximity Read ↗

Manganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin.Semantic proximity Read ↗

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