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Article

CD40-activated macrophages become highly susceptible to X4 strains of human immunodeficiency virus type 1.

AIDS research and human retroviruses - 20 Jan 2002

Bakri Youssef, Mannioui Abdelkrim, Ylisastigui Loyda, Sanchez Françoise, Gluckman Jean Claude, Benjouad Abdelaziz

Abstract excerpt

Activating cells of the immune system may stimulate human immunodeficiency virus type 1 (HIV-1) replication and contribute to select pathogenic variants in vivo. Here, we examined the possible effect of a major pathway of immune activation, CD40 interaction with its ligand (CD40L), on the susceptibility of monocyte-derived macrophages (MDMs) to various HIV-1 strains. Stimulation of MDMs with CD40L led to reduced...

Read the complete abstract on PubMed

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Share to CD40 Antigens
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Macrophage Activation

Share to Macrophages

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Source

Identifiers

PMID: 11839143
DOI: 10.1089/08892220252779647

Genes

MIP
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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