[Diagnosis of a predisposition of retinoblastoma at the DNA level].

Abstract excerpt

Retinoblastoma is a malignant tumor that arises in the eyes of children at a frequency of about 1 in 15,000 live births in Japan. Thirty to 40 percent of the patients with retino-blastoma have a heritable predisposition to this tumor. This predisposition is determined by a germinal mutation in the RB gene, which was located at q14 region of chromosome 13 and isolated in 1986. Retinoblastoma will develop in about...

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