Article
[Diagnosis of a predisposition of retinoblastoma at the DNA level].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Jan 1991
Murakami Y
Abstract excerpt
Retinoblastoma is a malignant tumor that arises in the eyes of children at a frequency of about 1 in 15,000 live births in Japan. Thirty to 40 percent of the patients with retino-blastoma have a heritable predisposition to this tumor. This predisposition is determined by a germinal mutation in the RB gene, which was located at q14 region of chromosome 13 and isolated in 1986. Retinoblastoma will develop in about...
Topics
- DNA, Neoplasm
- DNA, Single-Stranded
- Eye Neoplasms
- Genes, Retinoblastoma
- Humans
- Mutation
- Nucleic Acid Conformation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- RNA, Messenger