Article
Chromosomal aberrations and hprt mutant frequencies in long-term American thorotrast survivors.
International journal of radiation biology - 1 Jul 2000
Platz E A, Wiencke J K, Kelsey K T, Janower M L, Schottenfeld D, Travis L B, Goldman M B
Abstract excerpt
PURPOSE: Patients injected with thorotrast, a radiologic contrast medium used from the 1920s to early 1950s, received chronic internal exposure to thorium-232, an alpha-emitter. Epidemiologic studies have observed markedly elevated risks of death from hepatic and hematologic cancers and extensive chromosomal damage among these patients. Few investigations have correlated multiple measures of genetic damage to...
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