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Article

Chromosome instability in fibroblasts derived from Li-Fraumeni syndrome families without TP53 mutations.

British journal of cancer - 1 Nov 2000

Boyle J M, Spreadborough A, Greaves M J, Birch J M, Scott D

Abstract excerpt

The mean in vitro lifespan of dermal fibroblast strains derived from cancer-affected individuals belonging to families conforming to the classical Li-Fraumeni-syndrome or the Li-Fraumeni-like syndrome (LF strains), but in whom no TP53 mutation has been found, was not significantly different to that of normal strains. This was in contrast to LF strains that carry TP53 mutations. Cytogenetic observations of...

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Identifiers

PMID: 11027425
DOI: 10.1054/bjoc.2000.1444
PMCID: PMC2363597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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