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Article

Avoidance or adaptation of radiotherapy in patients with cancer with Li-Fraumeni and heritable TP53-related cancer syndromes.

The Lancet. Oncology - 1 Dec 2021

Thariat Juliette, Chevalier Francois, Orbach Daniel, Ollivier Luc, Marcy Pierre-Yves, Corradini Nadege, Beddok Arnaud, Foray Nicolas, Bougeard Gaelle

Abstract excerpt

The management of patients with cancer and Li-Fraumeni or heritable TP53-related cancer syndromes is complex because of their increased risk of developing second malignant neoplasms after genotoxic stresses such as systemic treatments or radiotherapy (radiosusceptibility). Clinical decision making also integrates the risks of normal tissue toxicity and sequelae (radiosensitivity) and tumour response to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34856153
DOI: 10.1016/S1470-2045(21)00425-3

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